Which types of adult stem cells are used?

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Our protocols all three major types of adult stem cells at our disposal:

  • Human Umbilical Cord -derived Stem Cells
  • Adipose-derived Stem Cells (from patient’s fat)
  • Bone Marrow-derived Stem Cells

Our protocols leverage both expanded (in the lab, grown into larger numbers) and unexpanded stem cells.

Stem cells reside in adult bone marrow and fat, as well as other tissues and organs of the body. These cells have a natural ability to repair damaged tissue, however in people with degenerative diseases they are not released quickly enough to fully repair damaged tissue. In the case of fat stem cells they may not be released at all. The process of actively extracting, concentrating and administering these types of stem cells have the potential for beneficial effects in degenerative conditions.

Adult stem cells

Mesenchymal stem cells from our lab

Mesenchymal stem cells from our lab

Adult stem cells can be extracted from many areas of the body, including the bone marrow, fat, and peripheral blood. Once the cells have been harvested, they are sent to the lab where they are purified and assessed for quality, count, and safety (aerobic bacteria, anaerobic bacteria and endotoxin). Stem cells isolated from the human umbilical cord, bone marrow or fat have the ability to become different cell types (i.e. nerve cells, liver cells, heart cells, and cartilage cells). Scientific studies have also shown that these cells are capable of homing to and repairing damaged tissue. Animal studies have shown that these stem cells also secrete proteins and peptides that stimulate healing of damaged tissue, including heart muscle and spinal cord.

Human umbilical cord tissue (HUCT) stem cells

Umbilical cord stem cells reside in the *umbilical cords of newborn babies. HUCT stem cells, like all post-natal cells, are “adult” stem cells.

The Stem Cell Institute researches cord-derived mesenchymal stem cells that are separated from the umbilical cord tissue. These cells can be used after separation from the cord tissue or expanded into greater numbers under very strict, internationally recognized guidelines.

Mesenchymal stem cells from the umbilical cord tissue have been shown to help reduce inflammation, modulate the immune system and secrete factors that help the central nervous system to regenerate.

Because HUCT stem cells are less mature than other cells, the body’s immune system is unable to recognize them as foreign and therefore they are not rejected. There are no documented cases of any human rejecting allogeneic umbilical cord-derived mesenchymal stem cells. In the lab, HUCT stem cells also proliferate/differentiate more efficiently than “older” cells, such as those found in the bone marrow and therefore, they are considered to be potentially more “potent”.

*All donated cords are the by-products of normal, healthy births. Each cord is carefully screened for sterility and infectious diseases under International Blood Bank standards.

Fat derived stem cells

Fat stem cells are essentially sequestered and are not available to the rest of the body for repair or immune modulation. Fat derived stem cells have been used for successful treatment of companion animals and horses with bone and joint injuries for the last 5 years with positive results.

Adipose-derived stem cell

Adipose-derived stem cell

Experimental studies suggest fat derived stem cells not only can develop into new tissues but also suppress pathological immune responses as seen in autoimmune diseases.

 
 
Articles Authored by our scientists and physicians about Fat Derived Stem Cells:

Bone marrow stem cells

The bone marrow stem cell is the most studied of the stem cells, since it was first discovered to in the 1960s. Originally used in bone marrow transplant for leukemias and hematopoietic diseases, numerous studies and clinical trials have now expanded experimental use of these cells for conditions such as peripheral vascular disease, diabetes, heart failure, and other degenerative disorders.